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Research Technician/Analist (HLO)
The general aims of the division of Experimental Hematology are to obtain detailed knowledge on (molecular) mechanisms that determine hematopoietic stem cell self-renewal and differentiation, with the ultimate goal to deepen our insights in the development of human leukemias. We have a specific interest in dissecting the clonal heterogeneity of leukemias and recently developed tools that allow us to identify and prospectively isolate genetically distinct clones within individual patients. We perform gene-function analyses in human hematopoietic stem and progenitor cells isolated from cordblood and bone marrow utilizing various strategies including optimized retro/lentiviral transduction protocols and inducible RNAi and CRISPR/Cas9 approaches. We have a longstanding expertise in using molecular approaches (transcriptome, proteome and epigenome) to further understand processes such as hematopoietic differentiation, proliferation, apoptosis and self-renewal. We utilize a series of cell biological in vitro and in vivo model systems to be able to translate knowledge from our molecular research lines to more general concepts of hematopoietic stem cell biology. We anticipate that our studies will lead to a more rational approach in the clinic of this highly malignant disorder.
Job description
We are currently looking for a talented and highly motivated research technician on a project that will focus on epigenetic alterations in Acute Myeloid Leukemia. We aim to identify novel drugs that will more specifically target the leukemic stem cell. The research technician will work together in a team with other PhD students and a postdoc on this project.
What do we need
- HLO level
- Experience in cell biological techniques (e.g. eukaryotic tissue culture) is required
- Affinity with molecular biology techniques such as Western Blotting, molecular cloning, retroviral/lentiviral transduction protocols and flow cytometry is a pre
- You are enthusiastic, ambitious and you are a team player
What do we offer
Full-time contract for 1.5 years with possible extension afterwards.
Your salary will be a maximum of €3,184 gross per month (scale 7), depending on your qualifications and relevant experience, based on a full-time appointment.
In addition, the UMCG will offer you 8% holiday pay, and 8.3% end-of-year bonus.
The conditions of employment comply with the Collective Labour Agreement for Medical Centres (CAO-UMC). English: http://www.nfu.nl/english/about-the-nfu/
More information
For more information please contact:
Prof. dr. J.J. Schuringa, phone number: (050) 361 9391, e-mail: j.j.schuringa@umcg.nl (please do not use for applying)
Applying for a job
Please use the the digital application form at the bottom of this page - only these will be processed.
You can apply until 1 December 2019.
Within half an hour after sending the digital application form you will receive an email- confirmation with further information.